- After  a few procrastinations, Manuel yielded to the demands of the Spanish crown and on December 5, 1496, signed the edict condemning the Jews at the beginning within a few months. It seems, however, that the sovereign was not satisfied to deprive his kingdom of this new population (from Spain) very useful. Portugal did not have a middle class, and the skills brought by the Jews proved to be of great benefit. Thus, finally, all the Jews of the country were forcibly converted to Christianity in 1497, without any other possibility being left to them.
- In October  1497, there were officially no Jews left in the Iberian Peninsula, with the exception of the Kingdom of Navarre. Under the pressure of his powerful neighbors, the latter was forced to promulgate the last decree of Iberian expulsion, giving the Jews of Navarre until March 1498 to leave the country or to convert to Christianity.
(extract of the psalm 121 associated to this generation, verse 1 )
- A song for ascents. I shall raise my eyes to the mountains, from where will my help come?
But if the Jews of the generation of the Great Plague had had to resolve to exile, especially German lands to Poland, this generation that suffered a bane at least comparable to that of the generation of the great plague at the human level sees the exile of the Jews of Spain and Portugal to many horizons, including northern Europe, precisely accessible by crossing the Pyrenees, forbidden to Jews but allowed to (new) Christians.
- The trip  to the Mediterranean destinations was not a part of pleasure. A passage of « Chevet Yéhoudah » illustrates well the tribulations of the refugees. The chronicler, Shlomo Ibn Verga, relates many tragic episodes which, authentic or not, reflect the suffering of a generation having seen his world suddenly destroyed. In one case, says Ibn Verga, the owner of a rinderpest-filled refugee boat abandoned the Jewish passengers at a desolate spot on the coast, where the majority of them died of starvation. The survivors set off in search of an inhabited place:
(extract of the psalm 121 associated to this generation, verses 2 to 4 )
- My help is from the Lord, the Maker of heaven and earth.
- He will not allow your foot to falter; Your Guardian will not slumber.
- Behold the Guardian of Israel will neither slumber nor sleep.
At the same time as the Jewish adventure ends in Spain, the world opens. Outside the known continents of Europe and Asia, the world extends to the New World, the name given to the Americas. New world including Africa which only the Mediterranean rim, the East and some shores in the west were really known before. Explorations in Africa will allow, for the misfortune of the African populations, the settlement of the Americas. These discoveries will change the course of modern history.
(extract of the psalm 121 associated to this generation, verses 5 and 6 )
- The Lord is your Guardian; the Lord is your shadow; [He is] by your right hand.
- By day, the sun will not smite you, nor will the moon at night.
(extract of the psalm 121 associated to this generation, verses 7 and 8 )
- The Lord will guard you from all evil; He will guard your soul.
- The Lord will guard your going out and your coming in from now and to eternity.
 Esther Benbassa and Aron Rodrigue: « History of the Sephardic Jews ». Chapter: « The end of Sefarad? « . (French: Esther Benbassa et Aron Rodrigue : « Histoire des Juifs sépharades ». Chapitre : « La fin de Sefarad ? ». (p. 49-51) ).
 (led by) Shmuel Trigano: « The Sephardic World – I, History ». Chapter of Yom Tov Assis: « The Expulsion of Jews from the Iberian Peninsula ». (French: « Le monde sépharade – I, Histoire ». Chapitre « L’expulsion des Juifs de la péninsule Ibérique». (p. 207,208) ).
 (led by) Shmuel Trigano: « The Sephardic World – I, History ». Chapter of Yom Tov Assis: « The Expulsion of Jews from the Iberian Peninsula ». (French: « Le monde sépharade – I, Histoire ». Chapitre « L’expulsion des Juifs de la péninsule Ibérique». (p. 204,205) ).